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[e-med] Don de zythromax par Pfizer

E-MED: Don de zythromax par Pfizer

Résumé en français

Dans le cadre de l'éradication des infections occulaires responsables de la
cécité, Pfizer a fourni 8 millions de doses de zithromax dans le cadre de
l'Initiative Internationale contre le trachome pour traiter les malades de 9
pays pauvres d'Afrique et d'Asie (sans préciser lesquels). Le président
directeur général pense mettre à disposition de l'initiative internationale
135 millions de doses supplémentaires de zithromax sur les 5 ans à venir. Le
trachome qui a été largement éradiqué reste néanmoins prévalen dans 48 pays
pauvres d'Afrique, Asie et Amérique latine, là où les conditions d'hygiène
sont insuffisantes.
Le trachome est causé par la bactérie chlamidia trachomatis; il est transmis
par les mains sales, les mouches, les vêtements à partir des sécrétions
occulaires et nasales de personnes déjà infectées. Non traité, il entraîne
des lésions cornéennes qui conduisent à la cécité.
Le trachome a été tout d'abord traité par la tétracycline en pommade
ophtalmique, mais il nécessite pour cela 5 à 7 applications quotidiennes
pendant 10 jours ce qui pose des problèmes d'observance au traitement.
En revanche, le zithromax, une prise unique orale de solution buvable pour
l'enfant ou de 4 gélules en une seule fois pour l'adulte, entraîne la

-----Message d'origine-----
De : owner-afro-nets@healthnet.org
[mailto:owner-afro-nets@healthnet.org]De la part de Claudio Schuftan
Envoyé : mardi 25 novembre 2003 12:08
À : afro-nets@satellife.healthnet.org
Objet : AFRO-NETS> Pfizer Offering Free Eye Antibiotic to poor countries in
Africa & Asia

Pfizer Offering Free Eye Antibiotic to poor countries in Africa & Asia

UNITED NATIONS (AP) -- In a major boost to a U.N. campaign to eradicate an
eye infection that causes blindness, Pfizer announced that it will provide
an antibiotic free to treat about 90 percent of the 150 million people

The international organization leading the fight against trachoma-related
blindness said it is "enthusiastic" that with the medicine it can now
achieve the goal set by the World Health Organization of eliminating the
ancient scourge by 2020.

Over the last five years, the pharmaceutical giant has provided eight
million doses of the antibiotic Zithromax to the International Trachoma
Initiative to treat sufferers in nine impoverished countries in Africa and

Hank McKinnell, Pfizer's chairman and chief executive officer, told a news
conference Tuesday that the initial program had been so successful that
Pfizer would donate 135 million additional
doses of Zithromax over the next five years.

"That represents a 15-fold increase and the largest donation of a patented
medicine in history," he said.

Zithromax is an antibiotic that is used primarily to treat respiratory tract
infections in children. It has over $2 billion in worldwide sales annually,
McKinnell said.

McKinnell said the 8 million doses, plus other support to the initiative
from Pfizer over the last five years, was worth about $300 million in
wholesale prices in the countries where Zithromax was distributed.

He refused to put an estimate on the value of the 135 million additional
doses, but another Pfizer executive said it runs into "many hundreds of
millions" of dollars.

Serge Reznikoff of the World Health Organization called the Pfizer
announcement "very exciting and promising."

Over the past century, trachoma was eliminated in many countries, including
virtually all of the Americas, Europe and Australia. In the early 1900s,
infected immigrants were barred from entering
the United States and trachoma was a major public health concern until it
was eradicated over a half century ago.

But it is still prevalent in 48 countries in the poorest parts of Africa,
Asia and Latin America where clean water and sanitation are scarce.

Trachoma is caused by the bacterium Chlamydia trachomatis which can be
spread easily by hands, clothing, or flies that have come into contact with
discharges from the eyes or nose of an infected person. Over time, it
results in turned-in eyelashes which then scratch and scar the cornea,
leading to blindness if not treated.

Trachoma was initially treated with tetracycline ointment in the eye, but it
required five to seven applications daily for 10 days and McKinnell said the
compliance with this regime was "terrible."

He said Zithromax represented a major step forward because it can be
administered in a one-time single dose -- either an oral solution for
children or four pills taken together.

"With a single dose you have a cure which is quite dramatic," McKinnell
said, explaining that Zithromax eliminates the Chlamydia that causes
blinding trachoma.

The International Trachoma Initiative is a partnership among Pfizer, the
Edna McConnell Clark Foundation, national governments and non-governmental

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