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[e-drug] Information note on delayed haemolytic anaemia following treatment with artesunate

E-DRUG: Information note on delayed haemolytic anaemia following treatment with 
artesunate 
-----------------------------------------------------------------------------------------

Information note on delayed haemolytic anaemia following treatment with
artesunate (WHO)
October 2013

Authors:
World Health Organization

Publication details
Number of pages: 2
Publication date: 2013
Languages: English, French

Introduction
Injectable artesunate is a life‐saving therapy for patients with severe 
Plasmodium falciparum malaria, providing a substantial reduction of mortality. 
In the two largest randomized controlled trials conducted in patients with 
severe malaria, parenteral artesunate treatment reduced deaths by 34.7% (in the 
Asian SEAQUAMAT trial) and by 22.5% (in the African AQUAMAT trial) compared 
with parenteral quinine.1,2 WHO currently recommends artesunate (intravenous or 
intramuscular) as the first line treatment for the initial management of severe 
malaria.3

A number of cases of delayed haemolytic anaemia have been identified following 
treatment of severe malaria with injectable artesunate. The Medicines for 
Malaria Venture (MMV), in March 2013, convened a meeting of experts to review 
the available evidence on delayed haemolytic anaemia following treatment with 
injectable artesunate. 

The full report of the MMV convened expert meeting is available on the MMV 
webpage (http://www.mmv.org/newsroom/events/expert-group-meeting- 
safety-profile-injectable-artesunate).

This information note reflects the current WHO position based on the outcome of 
the review meeting and consultation with the Co-Chairs of the GMP Technical 
Expert Group on Malaria Chemotherapy.

Downloads
* Information note on delayed haemolytic anaemia following treatment with
artesunatepdf, 336kb
<http://www.who.int/entity/malaria/publications/atoz/who_note_delayed_haemo
lytic_anaemia_oct13.pdf>
 <http://www.who.int/malaria/publications/atoz/who_note_haemolytic_anaemia/
en/index.html#>

Carinne Bruneton <c.bruneton@remed.org>

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