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[e-drug] Prescrire International July Issue

E-DRUG: Prescrire International July Issue
------------------------------------------

Go to english.prescrire.org for the contents of the latest issue of Prescrire 
International.

Prescrire is a non-profit, continuing education organisation that is completely 
independent of any ties to government or industry. Prescrire's managers and 
editorial staff sign a yearly statement certifying that they have no conflicts 
of interest. Prescrire's publications accept no advertising, grants or other 
outside support or any kind.

Prescrire International is totally funded by subscribers, with no support from 
the pharmaceutical industry or government. It is monthly and published 11 times 
a year. Health professionals in low-income countries (excluding drug companies) 
can benefit from a subscription to Prescrire International thanks to Solidarity 
Subscription Rates.

You will find full subscription details at english.prescrire.org

Contents of the July issue include:

EDITORIAL
==========
Early signals
Hasty regulators gambled on aliskiren's harms and benefits
FREE

NEW PRODUCTS
==============
Belatacept
In kidney transplantation: more risky than ciclosporin

INN common stem: -piprazole

Aliskiren: negative trial data
A do-not-use drug

Flurbiprofen without a prescription for dysmenorrhoea: rejected by French drugs 
agency
A wise decision

Sildenafil and pulmonary hypertension in children
First, do no harm

Topical fluticasone for infants from 3 months of age
Inadequate assessment

Prescrire's comments

Amlodipine + aliskiren
Still no evidence that aliskiren reduces morbidity or mortality

Naproxcinod
No authorisation in the European Union

Pioglitazone: European approval maintained despite the acknowledged risks
Chaotic regulation

ADVERSE EFFECTS
================
Calcium channel blockers + macrolides: elderly patients hospitalised for low 
blood pressure
Avoid erythromycin and clarithromycin

Domperidone: ventricular arrhythmia and sudden death
Do not use
FREE

Alcohol-based hand sanitizers: severe intoxication in children
Keep out of reach

NSAIDs: miscarriage (continued)
NSAIDs should not be used at any time during pregnancy

Vitamin E and prostate cancer
Unfavourable harm-benefit balance

Fluoroquinolones and tendon disorders: even after single-dose therapy
3 times more reports involved pefloxacin

REVIEWS
========
Paracetamol during pregnancy: no particular danger
for the child

Paracetamol exposure in utero or during infancy:
no increase in asthma

OUTLOOK
=========
Corporate influence over clinical research: considering the alternatives
Funding drug research independent of drug companies: a pipe dream or a public 
health necessity?
FREE

The exorbitant price of cancer drugs
No correlation with therapeutic benefits
FREE

MASTHEAD
==========
FREE


Bruno TOUSSAINT
Editorial Director
Prescrire
75558 PARIS CEDEX 11
FRANCE



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