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[e-drug] KENYA: Malaria drug effectiveness hit by under-dosage

E-DRUG: KENYA: Malaria drug effectiveness hit by under-dosage



NAIROBI, 12 March 2012 (IRIN) - Lack of adherence to the full course of
Artemisinin-based combination therapy (ACT) treatment is threatening the
effectiveness of the drug recommended as first-line treatment for
uncomplicated malaria in countries where the disease is endemic, according
to recent studies.

In Siaya district of western Kenya, where malaria is particularly prevalent
(38 percent incidence in 2010), a study revealed that only 47 percent of
participants reported completing the given doses. 

"There have always been concerns about whether patients are fully adhering
to their treatment regimens once they receive the recommended
Artemisinin-based combination therapy. Our study reveals that adherence is
poor among many patients," Eric Onyango, lead researcher, told IRIN.

The study investigated ACT adherence levels, factors associated with
non-adherence and household access to ACT. It involved 297 participants, all of 
whom had tested positive to Plasmodium falciparum, the parasite
responsible for causing malaria, at the time of the study. A household's
education level was found to be the highest predictor of poor adherence.
Others included household income and age.

Another study (http://www.malariajournal.com/content/pdf/1475-2875-10-281) 
carried out in five outpatient government health clinics in two Kenyan
districts, all with high malaria prevalence, concluded that while 64.1
percent of the 918 patients included in the study were probably adherent,
the rate was lower than that of previous studies.

The authors concluded that "targeted information, education and
communication activities at the community level may help to increase
awareness of the treatment regimen and its uptake, and reduce the risk of
contributing to the development of parasite resistance".

Early treatment

According to health experts, proper adherence to malaria treatment drugs is
important in improving treatment outcomes, reducing cases of drug resistant
malaria and controlling the disease.

"People who have malaria infection should always be diagnosed in good time
and put on treatment early. If they fail to adhere to their treatment, there 
could be increased cases of drug-resistant malaria, which affects better 
treatment outcomes and the management of the disease," Andrew Sulleh, a doctor, 
told IRIN.

"People are likely to adhere when they seek treatment early. This means it
is important that they are educated on the symptoms of possible malarial
infection so that they are able to seek early diagnosis and treatment," he

In 2010, malaria caused 655,000 deaths, many of them in Africa, where the
disease accounts for 22 percent of all childhood deaths, according to the
World Health Organization (WHO).

Effective drug

Many malaria-endemic countries in Africa have switched to ACT, after malaria 
parasites developed resistance to mono-therapies. The WHO estimates that in 
2010 alone, some 181 million courses of ACT were procured worldwide in the 
public sector.

While some earlier studies done soon after the roll-out of ACT have shown high 
prevalence -change to - adherence rates of up to 75 percent, health workers say 
the high number of tablets involved in ACT regimens to complete a full 
three-day dose could be contributing to poor adherence. Adult patients are 
expected to take eight tablets a day within eight hours for three days, while 
children take four tablets daily within a similar period. 

"The tablets that a patient is expected to take daily are very many and they 
are unpalatable and this makes others just take the medicine for a short time 
and throw away the rest. Some also feel they are fine after taking a few 
tablets and stop their medication halfway," said Lillian Natembea, a nursing 
officer at the Kenyatta National Hospital, Kenya's largest referral facility. 

In a small study in rural Ethiopia, 37.3 percent of the patients who were
reported as definitely non-adherent blamed the many tablets, while another
25 percent said they did not continue because they felt better before
finishing the dose. 

Health officials say patient education and counseling are important in
ensuring adherence to ACT regimens.

"What happens at the time of the interaction between the patient and the
healthcare worker is important in maintaining adherence. Health workers need to 
counsel and educate patients on how to take the drugs and on the
importance of completing their doses," said Sulleh, who is also head of the
Mbagathi District Hospital in Nairobi.


According to Elizabeth Juma, head of malaria control at Kenya's Ministry of
Public Health, proper malaria treatment is as important as malaria
prevention, saying strategies such as the use of insecticide treated
mosquito nets should be promoted.

"Proper treatment for those already infected with malaria is important, but
even more important is the promotion of prevention strategies like the use
of insecticide treated nets, which is still low in the country," she said.

The Kenya Malaria Indicator Survey 2010 shows that while 48 percent of
Kenyan households own at least one insecticide treated mosquito net, just 32 
percent use it.


[This report does not necessarily reflect the views of the United Nations]

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