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[e-drug] Prescrire International February issue

E-drug: Prescrire International February issue
----------------------------------------------

Go to www.english.prescrire.org<http://www.english.prescrire.org> for the 
contents of the latest issue of Prescrire International

Prescrire is a non-profit, continuing education organisation that is completely 
independent of any ties to government or industry. Prescrire's managers and 
editorial staff sign a yearly statement certifying that they have no conflicts 
of interest. Prescrire's publications accept no advertising, grants or other 
outside support or any kind.

Prescrire International is totally funded by subscribers, with no support from 
the pharmaceutical industry or government. It is monthly and published 11 times 
a year. Health professionals in low-income countries (excluding drug companies) 
can benefit from a subscription to Prescrire International thanks to Solidarity 
Subscription Rates.

You will find full subscription details at 
www.english.prescrire.org<http://www.english.prescrire.org>

Contents of the February issue include:


CONTENTS
========

EDITORIAL
=========

With more follow-up
Calling initial assessments into question
FREE

NEW PRODUCTS
============

Saxagliptin (type 2 diabetes)(New Drug)
No more effective than other gliptins, but a high potential for drug 
interactions

Imatinib (adjuvant therapy after surgical excision of gastrointestinal stromal 
tumour) (New Indication)
Too many unknowns

Common stem: -trexed

Pemetrexed (maintenance therapy for non-small cell lung cancer) (New Indication)
Inadequately assessed, no proven advantages

Azacitidine (in myelodysplasia syndromes) (New Drug)
Promising, but more data needed

ADVERSE EFFECTS
===============

Drug-induced cataracts
Mostly corticosteroids, even after local or inhaled treatment

Drospirenone: high risk of venous thrombosis
Combined contraceptives: levonorgestrel and norethisterone are safer

Benfluorex: how many deaths?
Pulmonary arterial hypertension and valve damage
FREE

Dextropropoxyphene and cardiac disorders: new data
QT prolongation
FREE

REVIEWS
=======

Adjuvant chemotherapy for localised colon cancer

Fluorouracil + folinic acid for node-positive, non-metastatic disease


Management of uncomplicated hypertension during pregnancy
ACE inhibitors, angiotensin II receptor blockers and aliskiren must be avoided

OUTLOOK
=======
Treatment choices: specialist bias
Patients need access to balanced information
FREE

Facing obstacles, yet doing one's job properly
A number of stakeholders are daring to do the right thing
FREE

Perseverance
Prescrire challenges the EMA's secrecy

QUERIES AND COMMENTS: Activated charcoal adsorbs colchicine but does not 
replace gastric lavage

Pharmacovigilance in Europe: some progress, but a missed opportunity
FREE


Bruno TOUSSAINT
Editorial Director
Prescrire.
75558 PARIS CEDEX 11
FRANCE



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