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[e-drug] Status of Dextropropoxyphene?(2)

E-DRUG: Status of Dextropropoxyphene? (2)
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Dear E-druggers,

Dextropropoxyphene is a structurally similar weak opioid analgesic as 
propoxyphene with similar pharmacological profile and toxicity. There have been 
concerns for some years over the risk of death from overdose � both intentional 
and accidental � in patients taking medicines containing dextropropoxyphene and 
paracetamol.

Approx. one year ago, on 21 October 2009, the European Medicine Agency based on 
a safety review, recommended the withdrawal of all non-parenteral dosage form 
containing dextropropoxyphene in EU member countries. 

For the parenteral form (solution for injection) that is usually used in 
hospitals under controlled condition, it was recommended that the marketing 
authorisations be suspended until further data are available on its safety. 

You can find more details about this decision on EMA website 
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/public_health_alerts/2010/09/human_pha_detail_000014.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d126&jsenabled=true
 
Combination analgesic paracetamol (325 mg) and dextropropoxyphene (32.5 mg) 
known as co-proxamol was withdrawn from the market in Ireland as of January 
2006. 

This article analysing impact of withdrawal after January 2006 of this products 
on intentional drug overdose found positive benefits, supportive of the 
withdrawal decision

 Corcoran P et al., Use of analgesics in intentional drug overdose 
presentations to hospital before and after the withdrawal of distalgesic from 
the Irish market.BMC Clin Pharmacol. 2010 Mar 18;10:6. 
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858125/pdf/1472-6904-10-6.pdf ) 

Regards

Dr. Klara Tisocki, B.Pharm., M.Sc., Ph.D.
Consultants for Health and Development BV
Sisalbaan 5E
2352 AZ Leiderdorp, 
The Netherlands
Tel: +31 71 7503240
Mobile: +31 643 536597
Fax: +31 71 5233592
Email:tisockik@chd-consultants.nl, ktisocki@yahoo.ie
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