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[e-drug] Prescrire International, August 2007

E-DRUG: Prescrire International, August 2007

Prescrire International is the English language edition of the reference French 
journal la revue Prescrire. It contains comparative evaluation of new drug 
interventions, reviews of adverse effects, and papers on drug policy issues. 
Prescrire International is totally funded by subscribers, with no support from 
pharmaceutical industry or government. It is published six times a year and 
health professionals in low income countries can also benefit from the journal 
thanks to Solidarity Subscription Rates. Drug companies are excluded from 
applying to Solidarity Rates. 

Contents of Prescrire International, 

August 2007 Volume 16  N° 90

· Preventing the preventable    

The methotrexate lesson

New Products                                                                    
· Palifermin (oral mucositis)

Inappropriate evaluation                                                        
· Sunitinib (gastrointestinal stromal tumours and metastatic renal carcinoma)

For some gastrointestinal stromal tumours

· Sorafenib (second-line treatment of kidney cancer)

A last resort                                                                   
· Pioglitazone + metformin, Rosiglitazone + glimepiride, Pioglitazone + 
glimepiride (type 2 diabetes)

Combination products to avoid                                                   
Editor's opinion: Avoid prescribing glitazones to diabetes patients, either 
alone or in combination

· Clopidogrel (myocardial infarction) 

Editor's opinion: What a shame!

· Finasteride (benign prostatic hypertrophy)             

Sexual disorders                                                                
· Lopinavir + ritonavir tablets (new formulation)   

A formulation suited to hot climates

· Nasal azelastine for self-medication      

Modest symptomatic relief from rhinitis

Adverse effects                                                                 
· Oral methotrexate: preventing avoidable overdose  

Prescrire's proposals: Preventing oral methotrexate overdose

· Leukaemia due to mitoxantrone  

· Angiotensin-II receptor antagonist + diuretic + nsaid = danger       

· Epoetin: dose-dependent excess mortality    

· Chronic hepatitis B        

A wider range of therapeutic options

Prescrire's proposals: Management of chronic hepatitis B 

· Obesity: weight loss without drugs         

A balanced diet avoiding high-calorie foods, plus exercise

Prescrire's proposals: Helping obese patients to lose weight without drugs

· Juvenile idiopathic arthritis: some progress but still many uncertainties  

· Duplicate publications of the same trial        

About Prescrire
· Association Mieux Prescrire (AMP)

A professional movement aimed at promoting quality healthcare         

Guideline watch
· French Health Agency guidelines 

Separating the good from the bad       

· Drug treatment for type 2 diabetes:

French Health Agency's guidelines highlight heavily-promoted new drugs and 
ignore some clinical realities              

Health and society 
· Shaping diseases: marketing departments flex their wings 

Refuse commercially-motivated disease definitions          


Prescrire International is financed by subscription fees only. We cannot 
provide free subscriptions. Send us your name and address if you want to 
receive a sample issue.

An annual subscription covers six issues and a five-year index. 

Standard Subscription Rates :
Individuals = 112 Euros ou 148 USD
students      = 56 Euros ou 74 USD
Commercial institutions = 283 Euros ou 374 USD
Solidarity Subscription Rates for countries with purchasing power parity < 12 
500 USD*/ year according the world bank classification: 
Individuals  =  43 Euros ou 57 USD 
Students     =  31 Euros ou 41 USD
Institutions (Health organisations, universities) =  112 Euros ou 148 USD
Commercial companies = 283 Euros ou 374 USD

* To benefit from Solidarity subscription rates, the journal must be sent to 
countries that are not on the following list : EU countries (excepted Bulgaria 
and Romania) and Australia, Argentina, Brunei, Canada, Croatia, Hong Kong, 
Iceland, Israel, Japan, Korea Republic, Kuwait, Liechtenstein, New-Zealand, 
Norway, Oman, Puerto Rico, Qatar, United Arab Emirates, United States of 
America, Saudi Arabia, Seychelles, Singapore, Switzerland. 

Development manager 
83 boulevard Voltaire
75558 PARIS CEDEX 11
Tel. : 33 1 49 23 72 65
Fax : 33 1 49 23 76 48
E-mail : international@prescrire.org
Website : www.prescrire.org 

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