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[e-drug] Research study on Artemisinin - seeking suitable laboratory

E-DRUG: Research study on Artemisinin - seeking suitable laboratory
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Dear e-druggers

action medeor - German Medical Aid Organization in conjunction with Advanced 
Bio-Extracts is currently conducting a research study on a cost-effective and 
environmentally friendly process for the manufacture of artesunate in East 
Africa.

For this research study we are seeking suitable laboratories. 
If you know laboratories it would be nice if you could pass on the following 
form.

Many thanks in advance
Christoph Bonsmann
Action Medeor
Germany
Christoph.Bonsmann@medeor.org

Notice: 2007-06A 

Advanced Bio-Extracts Limited
action medeor - German Medical Aid Organization

Name of the project:
Development of a Manufacturing Process for Artesunate: Laboratory Services

Interested companies are hereby invited to submit expressions of interest.
Applicants  will receive the full project description (Terms of References) and 
will be formally invited to submit proposals.
The company is requested to fill in and return the questionnaire at the end of 
the document. 

Brief project description:
The objective of this development study is to identify a cost-effective and 
environmentally friendly process for the manufacture of artesunate in East 
Africa.
Because the procedure for the reduction of artemisinin to dihydroartemisinin 
[DHA] on a large-scale is already available, the activities should focus on the 
conversion of DHA to artesunate by avoiding halogenated solvents.
In the first phase of the study, the feasibility of the conversion DHA → 
artesunate is to be demonstrated on a 20-g scale.
In the second phase, the scale up of the identified procedure is to be 
performed on a 10-L scale. 
Artemisinin (5 kg), analytical reference samples for DHA and artesunate, as 
well as the analytical specifications for artesunate will be provided. 

After the first phase (feasibility study) an assessment will be made to 
determine if and to which laboratory the scale-up-study will be contracted. 
A detailed tender dossier can be requested by filling in and returning the form 
at the end of the invitation.

The rules for awarding contracts as well as the evaluation and award criteria 
are explicitly defined in the tender dossier. 
action medeor reserves the right not to short list firms that have been found 
to have engaged in corrupt or fraudulent practices regardless of the results of 
technical evaluation of the expressions of interest.
Expressions of Interest are to be sent to:

action medeor e.V.
St. Toeniser Str 21
47918 Toenisvorst
Germany
Email: christoph.bonsmann@medeor.org 
 

Please fill in the following questionnaire 

Company name:
Full postal address:
Office/manufacturing address:
Website:
Email:
Contact person /email:
Core competences / brief company description (company brochure can be 
attached):        
Founded when:
Total number of staff:
Number of engineers:
Development laboratory available:       
Scale of laboratory:
Experience on derivatisation of artemisinin available:  
Analytical lab available:
Analytical experience on artemisinin derivatives:
Ability to provide an offer with an accuracy of +/-15%:
Filled in by (name, position):
Filled in on date:      

Closing date: 
After filling in and returning the above questionnaire the bidder will receive 
the terms of reference on which you can quote. 
The closing date for a quotation is July 5th 2007, 12.00h Central European 
Summer Time (CEST).

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