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[e-drug] Meningococcemia (2)

E-DRUG: Meningococcemia (2)
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I can only help with your second question. There are actually three drugs
that are recommended for prophylaxis: rifampin, ceftriaxone  and
ciprofloxacin. Here is some dosing information for each along with
references:

rifampin           
    Adults and children                         10 mg/kg, b.i.d. x 2 days
                                                (maximum 600 mg/day)

    Children <1 month                           5 mg/kg,, b.i.d. X 2 days
or            

ceftriaxone
    Adults                                      5 mg/kg, I.M., single dose
                                                (maximum 250 mg)
    Children <15 years                          125 mg, I.M., single dose
or            

ciprofloxacin      
    Adults                                      500 mg, single dose


1.             Advisory Committee on Epidemiology. Guidelines for control of
meningococcal disease. Canadian Communicable Disease Report 1994;20:17-27.
2.             Schwartz B, Al-Tobaiqi A, Al-Ruwais A, et al. Comparative
efficacy of ceftriaxone and rifampin in eradicating pharyngeal carriage of
group A Neisseria meningitidis. Lancet 1988;1:1239-42.
3.            National Health and Medical Research Council. Guidelines for
the control of meningococcal disease in Australia. Canberra: Australian Govt
Publ Serv; 1996.


-- 
Joel Lexchin MD
121 Walmer Rd.
Toronto ON
Canada M5R 2X8
Tel: 416-964-7186
Fax: 416-923-9515
E mail: joel.lexchin@utoronto.ca

[Thanks, Joel! WB]

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