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[e-drug] RFI: quinine syrup

E-DRUG: RFI: quinine syrup
------------------

hi 

I have been looking for information regarding with quinine syrup but i have got 
nothing, if possible let me have some website where these information can be 
readily available.
 
thank you

Betty Njau
mriab76@yahoo.com

[Please check the E-drug archives as some questions have been answered before 
at: http://www.essentialdrugs.org/edrug/
For example, see:
http://www.essentialdrugs.org/edrug/archive/199901/msg00049.php

We found these two formulae in the "Practical Pharmacy" Issue No. 7:

Formula A - using quinine dihydrochloride powder

Quinine dihydrochloride BP ........................12.2g
Sodium Benzoate ...........................................1.0g
Water ..........................................................200ml
Syrup BP .........................to 1000ml final volume

Method:
1. Dissolve the sodium benzoate in the water.
2. Dissolve the quinine dihydrochloride in the sodium benzoate
solution.
3. Mix well
4. Make upto volume with the Syrup BP
5. Mix well. Store in a dark glass, or opaque plastic bottle, with a
well fitting lid. Store away from bright light and heat.

Formula B - using quinine dihydrochloride injection (600mg/2ml)
Quinine dihydrochloride 600mg/2ml .........................35ml
Sodium Benzoate................................................ 1g
Water ......................................100ml
Syrup BP ...................................to 1000ml final volume

Method:
as above

A flavouring agent can be added (at stage 3 in the method). The
following could be used:
Concentrated Anise water........................................20ml
Concentrated Peppermint emulsion ........................25ml
Lemon spirit ..................................................10ml

Benzoic acid can be used instead of Sodium benzoate. The same
quantity is used.

I used formula B in the hospital. I found that a white flocculation
took place at the time of adding the quinine dihydrochloride to the
sodium benzoate solution. The Royal Pharmaceutical Society has
suggested that sodium benzoate be replaced by benzoic acid.

I trust these formulae will be useful to someone.

Yours,

Mahmood H.M. Daya, MRPharmS
Pharmacist
Ithnasheri Charitable Hospital
P.O. Box 7176
Arusha
Tanzania
Tel: (057) 2320/7692/6206
Fax (057) 4460
E-mail: dpl@habari.co.tz (personal)
ich@eoltz.com (hospital)

]
WB

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