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E-DRUG: E-DRUG Marijuana Side effects

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E-DRUG Marijuana Side effects

Att: Dr Andrew J.Meterhold

Title: Marijuana and cocaine impair alveolar macrophage function and 
cytokine production.
Source: American Journal of Respiratory & Critical Care Medicine.
156 (5) : 1606-13 , 1997 Nov.

"Studies using NG-monomethyl-L-arginine monoacetate , an inhibitor of 
nitric oxide synthase, suggest that alveolar macrophages (AMs) from 
nonsmokers and tobacco smokers were able to use nitric oxide as an 
antibacterial effector molecule , while AMs from smokers of marijuana 
and cocaine were not. Finally , AMs from marijuana smokers,  but not 
from smokers of tobacco or cocaine , produced less than normal 
amounts of tumor necrosis factor-alpha , granulocyte- macrophage 
colony-stimulating factor , and interleukin-6 when stimulated in 
culture with lipopolysaccharide".   
 
MEDICINES INFORMATION CENTRE GUEST
<micguest@uctgsh1.uct.ac.za>



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