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AFRO-NETS> RFI: Malaria Chemoprophylaxis (2)

RFI: Malaria Chemoprophylaxis (2)

Hi James,

I don't know exactly the type of research you are planning but I 
think you should be aware that the WHO has recommended that we pay 
less emphasis to Malaria chemoprophylaxis as this has not been shown 
to be very effective in stemming the tide of malaria in endemic ar-
eas. In pregnancy for example, WHO's three-pronged recommendations 
are: intermittent preventive treatment (IPT) with SP, use of insecti-
cide-treated bednets and case management with effective drugs out-
lined in individual country guidelines. 

The spread of chloroquine resistant malaria parasites is a big chal-
lenge to malaria chemoprophylaxis. Perhaps you will be interested in 
operations research that will increase access to IPT and ITNs in low-
resource settings. Use of these in pregnant women has been associated 
with decreased incidence of fever attacks, higher haemoglobin levels 
at birth, reduced incidence of low birth weight babies, increased 
mean birth weights and decreased maternal and infant mortality and 
morbidity. For IPT it is recommended that pregnant women take monthly 
doses of SP after 16th weeks of pregnancy during antenatal clinic at-
tendance. You may wish to consult the WHO for more information on the 

'Dipo Otolorin
JHPIEGO Corporation

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