RFI: Treatment of Multi-Drug-Resistant TB in pregnancy (2)
I forwarded the original request to listserve of ABS Medical Network.
One of our members was kind enough to send following reply:
From: Dr. Maqsood Bhatti
Date: Wed, 27 Jun 2001
Subject: Treatment of MDR-TB in pregnant woman
Dear Dr. Javaid Khan,
Unfortunately there is not much data available regarding safety of
second or third line anti-TB meds in pregnancy. Aminoglycosides and
quinolones are contraindicated. In few case reports Rifampin resis-
tant MTB has been shown to be sensitive to rifamycin. I saw an excel-
lent review article in "Clinical Infectious Disease 28(6):1298-304,
1999" reporting treatment of four pregnant women with MDR-TB. I am
sure this journal is available in Agha Khan University or you can e-
mail us your fax number; I will promptly send you a copy. Please also
review following five references for additional information on man-
agement of MDR-TB in pregnant patient.
1. Smith KC. Tuberculosis in children. [Review] [103 refs] Current
Problems in Pediatrics. 31(1):1-30, 2001 Jan. 21086744 Complete
2. Nitta AT. Milligan D. Management of four pregnant women with mul-
tidrug-resistant tuberculosis. Clinical Infectious Diseases.
28(6):1298-304, 1999 Jun. 99378379 Abstract | Complete Reference
3. Hageman JR. Congenital and perinatal tuberculosis: discussion of
difficult issues in diagnosis and management. [Review] [31 refs]
Journal of Perinatology. 18(5):389-94, 1998 Sep-Oct. 98437808 Ab-
stract | Complete Reference
4. Signorini L. Matteelli A. Bombana E. Pinsi G. Gulletta M. Tebaldi
A. Carosi G. Tuberculosis due to drug-resistant Mycobacterium bo-
vis in pregnancy. International Journal of Tuberculosis & Lung
Disease. 2(4):342-3, 1998 Apr. 98220162 Abstract | Complete Refer-
5. Abel SJ. Ward HE. Allen H. Pritchard R. Wheatley JR. Crawford H.
Development of multidrug resistant tuberculosis following super-
vised care: a case for directly observed therapy. Australian & New
Zealand Journal of Medicine. 26(2):228-9, 1996 Apr. 96314140 Com-
Good luck and looking forward to hear from you.
Maqsood A. Bhatti, M.D.
Medical College of Wisconsin
Division of Infectious Disease
I hope this will be helpful.
Mir Atta Muhammad Talpur
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